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Is Toxicity the root cause of all disease? Print E-mail
Ever visited a big city’s garbage dump on a hot summer day? Just the smell can make you feel sick. Removing that trash from urban streets makes a metropolis inhabitable. Left on the sidewalk, trash decomposes, providing a home for parasites, bacteria and other unsavory organisms.

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Toxic waste is constantly produced during normal processes like digestion and cellular respiration.
Sanitation of the Body

Well, the same basic removal process goes on inside your body. Garbage – toxic waste – is constantly produced during normal processes like digestion and cellular respiration. Damaging chemicals and other pollutants continually need to be removed.

Allowed to accumulate in tissues and organs, toxins make you sick, the same way a garbage strike makes a city odiferously unlivable. And that accumulation, researchers now believe, lies at the heart of disease and is the moving force behind illness.

The word toxin derives from the Greek word toxikon, a poison applied to arrows. In 1888, a Berlin doctor, Ludwig Brieger coined the word toxin to refer to poisons created within the body. Those poisons appear in your cells no matter how pure a life you lead. The very act of living makes their presence inevitable.

“We are constantly taking in oxygen, water and food for metabolism, and that process makes latent products that need to be dealt with,” observes Leonard Smith, MD, of Gainesville, Florida.

“Even if we lived in a pristine world with no chemicals, no air pollution, pure water, and pure food, still, with the passage of time we would experience cellular toxicity.”

How well is your body coping with toxins?

For evidence of how well or poorly your body is coping with toxins, Dr. Smith says you have to look no farther than your skin. Is it clear and glowing with healthy? Or does it look mottled, wrinkled and incorporate a disturbing pallor? “Looking at people’s skin, you get a good idea if toxins are coming out or are slowed down. A lot of people don’t think of the skin as a detox organ but it is, it’s the largest detox organ.” Many parts of the body participate in the teamwork of toxin removal. Dr. Smith recites a roster of organs that have to perform their jobs well for the body to effectively dispose of toxins, “The lungs, the kidneys, the bladder, the small and large intestines, colon, liver and gall bladder; all these organs eliminate toxins. When they don’t do their job, toxins get stuck in the organs and cause trouble for the cells. Cells under stress tend to work less efficiently.”


Researchers at the A.B. Hancock Jr. Memorial Research Center at Vanderbilt University in Nashville have identified a type of DNA damage caused by chronic inflammation as a probable risk factor for colorectal cancer. 2

In addition to coping with the natural production of toxins within the body, your body also has to deal with a constant bombardment of industrial waste products. Today, in the US, more than one out of every three rivers and lakes are unsafe to swim in because of pollution. The Environmental Protection Agency (EPA) reports that in 2002 (the latest year available) 24,379 U.S. facilities released 4.79 billion pounds of toxins into the atmosphere. Of these pollutants, 72 million pounds were known carcinogens.

These toxins impinge on health, during your entire life, even before birth. A study in New York City shows that the genetic material in fetuses still in their mothers’ wombs is damaged by air pollution.1 “These results raise serious concern,” warns Frederica P. Perera, MD, director of the Columbia Center for Children’s Environmental Health. “Fetal susceptibility to DNA damage from air pollution, including motor vehicle emissions and secondhand smoke, has important implications for cancer risk and developmental problems. And it underscores the importance of reducing levels of air pollution in our city.” Also underscored: the necessity for getting these pollutants out of your body.

Dangerous Process

Toxic build up is a dangerous process, some suggest that it can lead to cancer. “When cells are stressed long enough either the nucleus, cytoplasm or membrane may respond (malfunction) in reaction to the toxicity,” notes Dr. Smith. “If the cell reproduces and makes other cells that are all malfunctioning in similar ways an adenoma (small growth) may form. When a few more form, you may have a carcinoma or minimal cancer. But left long enough, it may progress to an undifferentiated, highly toxic cancer.” Undifferentiated cancers consist of cells that are primitive in nature and do not resemble the cells in the organs where they originated.

When this process moves into high gear, the results can be life threatening. Dr. Smith adds that, “As the cell tries to escape from unhealthy metabolism, the genetic machinery (may malfunction) leading to a whole spectrum of (undesirable) possibilities: cellular division that forms polyps or becomes a well-differentiated or undifferentiated cancer. Then, the cancer is likely to break into the lymphatic system and spread throughout the body.”

Inflammation can cause cancer


When the body experiences oxidative stress, molecules called free radicals are produced, and these free radicals can damage cells – the cell membrane and the DNA.


Lawrence J. Marnett, PhD, director of the Hancock Research Center
This type of stress on cells can result in inflammation, one of the body’s defense mechanisms designed to facilitate healing. Normally a response to injury or infection, inflammation stimulates the formation of cytokines, messenger proteins released by white blood cells that alert the immune system to attack an invader or heal wounds. But when chronic inflammation is ignited by toxins, the body can damage itself.

“Cancer can arise in sites of chronic inflammation: We believe that when inflammation occurs the body is in a fighting mode, ready to fight off germs. But when this is an inappropriate response, (when toxins set off inflammation), the oxidants produced (by the body) to attack the bacteria instead attack our own DNA and lead to mutation,” says William Joel Meggs, MD, PhD, professor and chief of toxicology at the Brody School of Medicine at East Carolina University in Greenville, North Carolina.

For instance, researchers at the A.B. Hancock Jr. Memorial Research Center at Vanderbilt University in Nashville have identified a type of DNA damage caused by chronic inflammation as a probable risk factor for colorectal cancer. 2  “These studies suggest a direct link between oxidative stress, like that seen in chronic inflammation, and genetic mutations that cause human disease," says Lawrence J. Marnett, PhD, director of the Hancock Research Center. “When the body experiences oxidative stress, molecules called free radicals are produced, and these free radicals can damage cells – the cell membrane and the DNA.”

Heartbreaking Toxins

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Toxins can enter one part of the body, the lungs, but cause eventual disease in another, such as the heart.
In a similar way, diseases like Alzheimer’s and heart disease have also been linked to excess inflammation.

Until recently, medical researchers didn’t understand that small amounts of toxins that we encounter everyday can lead to these severe problems. “(For example), small particulates (in air pollution), 2.5 microns and smaller (given off by diesel engines), can trigger inflammation at levels well below where they would be considered toxic in a more classical sense,” Dr. Meggs warns. “At the levels one finds in New York City or Houston, it’s enough to double the heart attack rate. We don’t know exactly how this low level triggers inflammation in the arteries of some people that leads to heart attacks while not happening in others.”

Confusing the issue, toxins can enter one part of the body, the lungs, but cause eventual disease in another, such as the heart. “It can start when white blood cells detect these (toxins) and signal the body that ‘we have a problem,’” Dr. Meggs observes. “That starts the inflammation process. But then a process called switching occurs: People are inoculated with something in one part of the body but then get an effect in another. Still, it hasn’t been proven how this switching mechanism occurs when these small particles enter the lungs but result in inflammation (and disease) in the arteries and heart.”

Toxic Complications

The large number of pollutants we encounter every day complicates our body’s toxin-elimination efforts. “We’re living in a toxic soup of polluted air, water, food and electromagnetic toxins,” says Dr. Smith. “There’s no end to the toxicity coming in to the body. So the foundation of what you should do (to defend yourself) is drink filtered water, eat organic food, use air filters, live around trees which are natural filter of the air.” Dr. Smith says that water is a crucial detoxification tool. “Drink half your body weight in ounces of water every day. If you don’t give your kidneys enough water, they will suck it out of the material in your bowels. Your kidneys need the water to hold toxins in solution and get them out. Urine can only be so concentrated. Without enough water, toxins are reabsorbed.”


We’re living in a toxic soup of polluted air, water, food and electromagnetic toxins. There’s no end to the toxicity coming in to the body. So the foundation of what you should do (to defend yourself) is drink filtered water, eat organic food, use air filters, live around trees which are natural filter of the air.
Dr. Leonard Smith
Natural ways to remove toxins

There are natural ways to support the removal of toxins from your body, including herbal cleansing formulas designed to support the body’s seven channels of toxin elimination: the bowels, blood, skin, kidneys, lymphatic system, lungs and the liver. Typically, these formulas include herbs that have been used historically to assist different parts of the bodies natural cleansing system. Many natural health practitioners recommend 7-channel cleanses at the beginning of each new season. Other daily cleansing support formulas include fiber, essential fats, digestive enzymes and probiotics all of which can help the body cope with its constant task of eradicating problematic toxins. Herbs like Triphala, red clover, dandelion, artichoke leaf, turmeric and milk thistle, also aid in toxin removal. In addition, lifestyle habits like daily exercise and stress reduction may aid in defending your body against toxins.

Even in a clean environment, the simple act of living is a sloppy business. Like workers at a city’s construction sites, your cells are constantly tearing down and building up body parts. New tissue is formed and old ones disposed of. To feed this kind of activity, your cells absorb nutrients, produce energy, synthesize natural chemicals and throw off waste products. Just as demolition debris and lunch break leftovers at a construction site have to be disposed of, the body needs to rid itself of waste products and metabolic scraps. Otherwise, like a new building that’s had garbage buried in its walls, it rots from within. But if you help your body relieve its toxic burden, you increase your chances of having a clean bill of health.

References

1. Env Hlth Persp, 6/04 
2. Proc Natl Acad of Sci, 11/4/03
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Torsten Forberger
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